X-Linked Lymphoproliferative Disease in Latvia: A Report of Two Clinically Distinct Cases
نویسندگان
چکیده
منابع مشابه
X-Linked Lymphoproliferative Disease
2B4 is a surface molecule involved in activation of the natural killer (NK) cell-mediated cytotoxicity. It binds a protein termed Src homology 2 domain-containing protein (SH2D1A) or signaling lymphocyte activation molecule (SLAM)-associated protein (SAP), which in turn has been proposed to function as a regulator of the 2B4-associated signal transduction pathway. In this study, we analyzed pat...
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X linked lymphoproliferative disease (XLP; Duncan's disease) is a rare disorder affecting boys and characterised by a defective immune response to Epstein-Barr virus caused by a mutation in a gene located at chromosome Xq25. Three siblings with XLP in a single UK family are reported and the variation in phenotypic expression of the disease in these siblings described. One of the siblings with l...
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ژورنال
عنوان ژورنال: Case Reports in Medicine
سال: 2020
ISSN: 1687-9627,1687-9635
DOI: 10.1155/2020/7108657